Investigating the brain’s neurochemical profile at midlife in relation to dementia risk factors

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Maria-Eleni Dounavi, Elizabeth McKiernan, Michael Langsen, Sarah Gregory, Graciela Muniz-Terrera, Maria Angeles Prats-Sedano, Marius Ovidiu Mada, Guy B Williams, Brian Lawlor, Lorina Naci, Clare Mackay, Ivan Koychev, Paresh Malhotra, Karen Ritchie, Craig W Ritchie, Li Su, Adam D Waldman, John T O’ Brien, Brain Communications (2024) DOI: https://doi.org/10.1093/braincomms/fcae138 Summary Changes of functional nature in the brain … Read more

Dementia risk and thalamic nuclei volumetry in healthy midlife adults: the PREVENT Dementia study

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Sita N Shah, Maria-Eleni Dounavi, Paresh A Malhotra, Brian Lawlor, Lorina Naci, Ivan Koychev, Craig W Ritchie, Karen Ritchie, John T O’Brien Brain Communications (2024) DOI: https://doi.org/10.1093/braincomms/fcae046 Summary The Thalamus is an area of the brain involved with several processes, such as cognitive function and sleep, and has been shown to be affected in the dementia … Read more

PallorMetrics: Software for Automatically Quantifying Optic Disc Pallor in Fundus Photographs, and Associations With Peripapillary RNFL Thickness

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Samuel Gibbon, Graciela Muniz-Terrera, Fabian S. L. Yii, Charlene Hamid, Simon Cox, Ian J. C. Maccormick, Andrew J. Tatham, Craig Ritchie, Emanuele Trucco, Baljean Dhillon, Thomas J. MacGillivray Neuro-ophthalmology (2024) DOI: https://doi.org/10.1167/tvst.13.5.20 Summary In dementia, nerve cells in the brain called neurons stop functioning properly, lose connections with other neurons, and eventually die prematurely. The eye … Read more

PREVENT Dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia

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Craig W Ritchie, Katie Bridgeman, Sarah Gregory, John T O’Brien, Samuel O Danso, Maria-Eleni Dounavi, Isabelle Carriere, David Driscoll, Robert Hillary, Ivan Koychev, Brian Lawlor, Lorina Naci, Li Su, Audrey Low, Elijah Mak, Paresh Malhotra, Jean Manson, Riccardo Marioni, Lee Murphy, Georgios Ntailianis, William Stewart, Graciela Muniz-Terrera, Karen Ritchie Brain Communications (2024) DOI: https://doi.org/10.1016/j.numecd.2023.07.020 Summary … Read more

Adherence to the Eatwell Guide and cardiometabolic, cognitiveand neuroimaging parameters: an analysisfrom the PREVENT dementia study

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Sarah Gregory, Alex Griffiths, Amy Jennings, Fiona C. Malcolmson, Jamie Matu, Anne-Marie Minihane, Graciela Muniz-Terrera, Craig W. Ritchie, Solange Parra-Soto, Emma Stevenson, Rebecca Townsend, Nicola Ann Ward, Oliver Shannon Nutrition & Metabolism (2024) DOI: https://doi.org/10.1016/j.numecd.2023.07.020 Summary The Eatwell Guide is the UK government’s recommendation for a healthy diet. Although other healthy patterns of eating have been … Read more

APOE ɛ4 exacerbates age-dependent deficits in cortical microstructure

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Elijah Mak, Maria-Eleni Dounavi, Grégory Operto, Elina T Ziukelis, Peter Simon Jones, Audrey Low, Peter Swann, Coco Newton, Graciela Muniz Terrera, Paresh Malhotra, Ivan Koychev, Carles Falcon, Clare Mackay, Brian Lawlor, Lorina Naci, Katie Wells, Craig Ritchie, Karen Ritchie, Li Su, Juan Domingo Gispert, John T O’Brien. Brain Communications (2024) DOI: https://doi.org/10.1016/j.numecd.2023.07.020 Summary The APOE ε4 … Read more

The indirect relationship between sleep and cognition in the PREVENT cohort: identifying targets for intervention

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Benjamin Tari, Michael Ben Yehuda, Axel Anders Stefan Laurell, Karen Ritchie, Yves Dauvilliers, Craig W. Ritchie, Brian Lawlor, Lorina Naci, Graciela Muniz Terrera, Paresh Malhotra, Tam Watermeyer, Robert Dudas, Benjamin R Underwood, John T O’Brien, Vanessa Raymont, Ivan Koychev. Frontiers in Sleep (2023) DOI: https://doi.org/10.1016/j.numecd.2023.07.020 Summary As the global population ages, it is critical to … Read more

PREVENT General Assembly 2023

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On the 6th October 2023 the PREVENT General Assembly was hosted by Prof Paresh Malhotra at Imperial College London. We had a great day hearing about all the recent analysis that is underway and the next steps planned for when the wave 2 follow-up data is released later this year. A core focus of the … Read more

The Mediterranean diet is associated with better cardiovasular health for women in mid-life but not men: A PREVENT dementia cohort cross-sectional analysis

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Sarah Gregory, Georgios Ntailianis, Oliver Shannon, Emma Stevenson, Craig Ritchie, Katie Wells, Graciela Muniz-Terrera Nutrition, Metabolism and Cardiovascular diseases (2023) DOI: https://doi.org/10.1016/j.numecd.2023.07.020 Summary A Mediterranean diet is rich in fruit, vegetables, pulses, olive oil and oily fish. People who eat this diet have been shown to have better cardiovascular health such as lower blood pressure … Read more

Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort

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Bauermeister, S.D., Yehuda M.B., Reid, G., Gregory, S., Howgego, G., Ritchie, K., Watermeyer, T., Muniz-Terrera, G., Koychev, I. British Medical Journal (2023) DOI: https://doi.org/10.1177/0271678X231173587 Summary This study sought to look at the relationship between pre-diabetes (that is resistance of the body tissue to insulin), depressive symptoms and performance on memory tests in 40-59 year olds. Blood … Read more

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