Hypothalamic volume, sleep, and APOE genotype in cognitively healthy adults

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Axel A. S. Laurell, Elijah Mak, Maria-Eleni Dounavi, Benjamin R. Underwood, Yves Dauvilliers, Robert B. Dudas, Oriane Marguet, Craig W. Ritchie, Ivan Koychev, Brian A. Lawlor, Lorina Naci, Paresh Malhotra, Oriol Grau-Rivera, Juan Domingo Gispert, John T. O’Brien for the ALFA study and the PREVENT Dementia Investigators Alzheimer’s & Dementia (2025) DOI: 10.1002/alz.70244 Summary Sleep problems … Read more

Intimate partner violence, traumatic brain injury and long-term mental health outcomes in midlife: the Drake IPV study

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Natalie D Jenkins, Craig W Ritchie, Karen Ritchie, Graciela Muniz-Terrera, William Stewart on behalf of the PREVENT Dementia Investigators BMJ Mental Health (2025) DOI: Intimate partner violence, traumatic brain injury and long-term mental health outcomes in midlife: the Drake IPV study | BMJ Mental Health Summary This study explored mental health conditions in individuals who … Read more

Association between choroidal microvasculature in the eye and Alzheimer’s disease risk in cognitively healthy mid-life adults: A pilot study

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Burke, J., Gibbon, S., Low, A., Hamid, C., Reid-Schachter, M., Muniz-Terrera, G., Ritchie, C.W., Dhillon, B., O’Brien, J.T., King, S., MacCormick, I.J.C, MacGillivray, T.J. Alzheimer’s & dementia (2025) DOI: https://doi.org/10.1002/dad2.70075 Summary The study explores whether there is a connection between the tiny blood vessels in the eye’s choroid (a layer behind the retina) and the … Read more

The pivotal role of sleep in mediating the effects of life stressors and healthy habits on allostatic load in mid-life adults

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Buller-Peralta Ingrid, Gregory Sarah, Low Audrey, Dounavi Maria-Eleni, Bridgeman Katie, Ntailianis Georgios, Lawlor Brian, Naci Lorina, Koychev Ivan, Malhotra Paresh, O’Brien John T., Ritchie Craig W., Dauvilliers Yves, Muniz-Terrera Graciela. Frontiers in Human Neuroscience (2024) DOI: https://doi.org/10.3389/fnhum.2024.1509223 Summary Allostatic Load (AL) is a way to describe the damage to your body that happens when you are … Read more

Texture-based morphometry in relation to apolipoprotein ε4 genotype, ageing and sex in a midlife population

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Maria-Eleni Dounavi, Elijah Mak, Gregory Operto, Graciela Muniz-Terrera, Katie Bridgeman, Ivan Koychev, Paresh Malhotra, Lorina Naci, Brian Lawlor, Li Su, Carles Falcon, Karen Ritchie, Craig W Ritchie, Juan Domingo Gispert, John T O’Brien. Human Brain Mapping (2024) DOI: https://doi.org/10.1002/hbm.26798 Summary In this study we investigated if subtle changes on MRI scans were associated with a risk … Read more

PREVENT 10 year anniversary celebrations

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February 2024 marked the 10 year anniversary of the PREVENT dementia programme, 10 years on from when our first participant joined the study. We wanted to spend this special year celebrating with our participants and researchers who have been involved in the project over the years. Therefore, throughout the year we hosted a series of … Read more

Brain age gap, dementia risk factors and cognition in middle age

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James D. Stefaniak, Elijah Mak, Li Su, Stephen F Carter, Maria-Eleni Dounavi, Graciela Muniz Terrera, Katie Bridgeman, Karen Ritchie, Brian Lawlor, Lorina Naci, Ivan Koychev, Paresh Malhotra, Craig W. Ritchie, John T. O’Brien Brain Communications (2024)   DOI: https://doi.org/10.1093/braincomms/fcae392 Summary ‘This study looked at “Brain Age Gap” (BAG) in middle-aged people. BAG is the difference between … Read more

Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease

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Qi Q, Deng F, Sammon R, Ritchie K, Muniz-Terrera G, Koychev I, Hutchinson S, Robinson D, Malhotra P. O’Brien J, Ritchie CW, Lawlor B, Naci, L. Alzheimer’s Research & Therapy (2024) DOI: https://doi.org/10.1186/s13195-024-01610-9 Summary Building cognitive reserve through stimulating activities and occupational attainment represents a crucial yet under-explored approach to dementia prevention in mid-life. However, it remains unclear whether modifiable lifestyle factors can protect against Alzheimer’s disease (AD) processes … Read more

Cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals

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Feng Deng, Karen Ritchie, Graciela Muniz-Terrera, Suzanne Hutchinson, Paresh Malhotra, Craig W Ritchie, Brian Lawlor, Lorina Naci. Neurobiology of Ageing (2024) DOI: https://doi.org/10.1016/j.neurobiolaging.2024.09.00610.1016/j.neurobiolaging.2024.09.006 Summary This study examined whether Alzheimer’s Disease (AD) risk factors were associated with cognition and functional connectivity (FC) between two key brain structures involved with the development of AD, the Locus Coeruleus (LC) … Read more

Neuroimaging and Clinical Findings in Healthy Middle-Aged Adults With Mild Traumatic Brain Injury in the PREVENT Dementia Study

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Audrey Low, Elizabeth McKiernan, Maria A. Prats-Sedano, Stephen F. Carter, James D. Stefaniak, Li Su,  Maria-Eleni Dounavi, Graciela Muniz-Terrera, Natalie Jenkins, Katie Bridgeman, Karen Ritchie, Brian Lawlor, Lorina Naci, Paresh Malhotra, Clare Mackay, Ivan Koychev, Tony Thayanandan, Vanessa Raymont, Craig W. Ritchie, William Stewart, John T. O’Brien. Jama Network Open (2024) DOI: 10.1001/jamanetworkopen.2024.26774 Summary Most traumatic … Read more

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