Cognition

The pivotal role of sleep in mediating the effects of life stressors and healthy habits on allostatic load in mid-life adults

by

Buller-Peralta Ingrid, Gregory Sarah, Low Audrey, Dounavi Maria-Eleni, Bridgeman Katie, Ntailianis Georgios, Lawlor Brian, Naci Lorina, Koychev Ivan, Malhotra Paresh, O’Brien John T., Ritchie Craig W., Dauvilliers Yves, Muniz-Terrera Graciela. Frontiers in Human Neuroscience (2024) DOI: https://doi.org/10.3389/fnhum.2024.1509223 Summary Allostatic Load (AL) is a way to describe the damage to your body that happens when you are … Read more

Associations between sex and lifestyle activities with cognitive reserve in mid-life adults with genetic risk for Alzheimer’s disease

by

Qi Q, Deng F, Sammon R, Ritchie K, Muniz-Terrera G, Koychev I, Hutchinson S, Robinson D, Malhotra P. O’Brien J, Ritchie CW, Lawlor B, Naci, L. Alzheimer’s Research & Therapy (2024) DOI: https://doi.org/10.1186/s13195-024-01610-9 Summary Building cognitive reserve through stimulating activities and occupational attainment represents a crucial yet under-explored approach to dementia prevention in mid-life. However, it remains unclear whether modifiable lifestyle factors can protect against Alzheimer’s disease (AD) processes … Read more

Insulin resistance, age and depression’s impact on cognition in middle-aged adults from the PREVENT cohort

by

Bauermeister, S.D., Yehuda M.B., Reid, G., Gregory, S., Howgego, G., Ritchie, K., Watermeyer, T., Muniz-Terrera, G., Koychev, I. British Medical Journal (2023) DOI: https://doi.org/10.1177/0271678X231173587 Summary This study sought to look at the relationship between pre-diabetes (that is resistance of the body tissue to insulin), depressive symptoms and performance on memory tests in 40-59 year olds. Blood … Read more

Modifiable lifestyle activities affect cognition in cognitively healthy middle-aged individuals at risk for late-life Alzheimer’s Disease

by

Amy Heneghan, Feng Deng, Katie Wells, Karen Ritchie, Graciela Muniz-Terrera , Craig W Ritchie, Brian Lawlor, Lorina Naci. Journal of Alzheimer’s Disease (2022). DOI: 10.3233/JAD-220267 Summary Mid-life lifestyle factors, including occupation, as well as engagement in physical, social and intellectual activities were evaluated. The impact of risk and protective lifestyle factors was measured in three aspects … Read more

Memory assessment and dementia risk in the PREVENT Study

by

Mario A. Parra, Graciela Muniz-Terrera, Samuel O. Danso, Karen Ritchie, Craig W Ritchie. Alzheimer’s & Dementia (2021) DOI: https://doi/epdf/10.1002/alz.055104 Summary The study assessed relational (face-name) and conjunctional (object-colour) memory markers in 183 participants from the PREVENT Dementia programme. Conjunctive measures included: the 4 Mountains test, Virtual reality supermarket task, name-face association test and the relational measure: … Read more

Higher midlife CAIDE score is associated with increased brain atrophy in a cohort of cognitively healthy middle-aged individuals

by

Xulin Liu, Maria-Eleni Dounavi, Karen Ritchie, Katie Wells, Craig W. Ritchie, Li Su, Graciela Muniz-Terrera & John T. O’Brien Journal of Neurology. 2021 DOI: https://doi.org/10.1007/s00415-020-10383-8 Summary Cardiovascular factors have a strong association with Alzheimer’s disease (AD) and brain atrophy. However, until recently, there has been limited longitudinal research in cognitive healthy middle-aged adults investigating these links. A recent PREVENT Dementia study used data from 167 … Read more

Protocol for a conversation-based analysis study: PREVENT-ED investigates dialogue features that may help predict dementia onset in later life

by

Sofia de la Fuente Garcia, Craig W. Ritchie, and Saturnino Luz BMJ Open. 2019 DOI: 10.1136/bmjopen-2018-026254  This publication lays out plans for the PREVENT Elicitation of Dialogues (PREVENT-ED) substudy. This project aims to analyse specific features of speech during conversation with PREVENT participants. The researchers seek to determine if there are any associations between changes … Read more

Allocentric and Egocentric Spatial Processing in Middle-Aged Adults at High Risk of Late-Onset Alzheimer’s Disease: The PREVENT Dementia Study

by

Karen Ritchie, Isabelle Carriere, David Howett, Li Su, Michael Hornberger, John T. O’Brien, Craig W. Ritchie and Dennis Chan. Journal of Alzheimer’s Disease 65 (2018) 10.3233/JAD-180432 [read more=”Read more” less=”Read less”] Some of the earliest brain regions to be affected by Alzheimer’s disease are thought to be those involved in memory and spatial orientation. Researchers … Read more

The midlife cognitive profiles of adults at high risk of late-onset Alzheimer’s disease: The PREVENT study.

by

Ritchie K, Carrière I, Su L, O’Brien JT, Lovestone S, Wells K, Ritchie CW. Alzheimer’s & dementia: the journal of the Alzheimer’s Association. 2017 10.1016/j.jalz.2017.02.008 Researchers analysed the results from PREVENT participants on various memory and thinking assessments. They found performance on particular spatial and navigation based tasks may be useful in differentiating between those … Read more

Cookie preferences